Mycobutin

(rifabutin)

    the

  • How to ce médrug is it ? What are its effects ?
  • the

  • Under what forms this médrug se présente-t-il ?
  • the

  • How should we use this médrug ?
  • the

  • In what case this médrug is it déadvisedé ?
  • the

  • What are the possible side effects of this médrug ?
  • the

  • Are there d'other prébonds d's employment, or warnings ?
  • the

  • D'other agents can interact with this médrug ?
  • MÉDICAMENTS
  • AFFECTIONS

How to ce médrug is it ? What are its effects ?

rifabutin belongs to the class of médrugs callés antibacténothings. Rifabutin is a médrug utilisé for précome and spread in the body of the disease à Mycobacterium avium complex in people with an infection à HIV (viruses immunodédisability human), or AIDS. These patients préfeel généusually a fièvre, night sweats, chills, weight loss, and a état général altéré.

It could be that your médecin has suggestedéré médrug for conditions not listed in this article information on the médrugs. In addition, some forms of this médrug may not &stop;tre utilisées for all of the conditions mentionedés in this article. If you don’t have to discussé with your médecin, or if you have any doubts about the reasons why you are taking this médrug, see-the. Do not stop taking this médrug without having to consulté your médecin préprovide prior.

Do not give this médrug à anyone, m&m stop;me à someone who suffers from the m&stop, my symptoms&taxes;my that the v&being limited to the very. médrug could be harmful for people to it has not été prescribed.

Under what forms this médrug se présente-t-il ?

Each capsule of géLatin farm of which the cap and the body are red-brown opaque, and bearing the inscription « PHARMACIA & UPJOHN/MYCOBUTIN » à white ink contains 150 mg of rifabutin. Apiéingredients non-médicinaux : microcrystalline cellulose, stéarate de magné, peptides or amino acids, red iron oxide, silica gel, lauryl sodium sulphate, titanium dioxide and white ink edible.

How should we use this médrug ?

The dose recommendedée to adult is 300 mg, once per day, with or without food. In case of nausées, vomiting, or upset stomach with this dose, take 150 mg two times per day with food. In children, the dose of rifabutin needs to &stop;tre déterminée médecin and adaptée à of each case. If this médrug is not taken régulièsurely, the appearance of side effects can &our vision to be the most fréquente and they can &our vision to be the most important qu’à the usual.

Several factors can be taken into account for définish the dose a person need : his weight, his état de santé and other médrugs. If your médecin has recommendedé a dose different from the ones indicatedées here, do not modify the manière taking the médrug without consulting préprovide prior.

It is important to use this médrug conformément aux indications of your médecin. If you miss a dose, take the médrug dès you see the failure and repeat the further processing as soon&taxes;t that possible. If it is almost time for your next dose, do not worry about the missed dose and go back to the schémy regular dosing. Do not use a double dose to compensate the missed dose. If you hép on the conduit à take après have omitted a dose, contact advice à your médoctor or to a pharmacist.

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Do not dispose of médrugs in the eaux usées (e.g. not in l’évier nor in the toilet) or with the rubbish ménagères. Ask à your pharmacist how you dérid of the médrugs inutilisés périmés.

In which case this médrug is it déadvisedé ?

please do not use this médrug in the circumstances ci-après :

    the

  • allergy to rifabutin or to any of the ingredientséingredients of this médrug .
  • the

  • allergy à médrug of the m&stop, me family (e.g. rifampin).

What are the possible side effects of this médrug ?

a Lot of médrugs can cause side effects. A side effect is a réponse indésirable à médrug when it is taken à normal doses. It can &stop;tre léger, or severe, temporary or permanent.

The side effects énumérés ci-après are not felt by all the people who take this médrug. If the side effects you worry aboutètent, discuss the risks and benefits of using this médrug with your médecin.

At least 1 % of people taking the médrug have signalé the side effects ci-après. A large number of these side effects can &our vision to be supported and some may disappear cool;tre of them-m&stop, my with the time.

view your médecin if you experience these side effects and they are severe or g&appear in the contaminants. Your pharmacist could be able to give you advice on the way to take if these side effects appeared :

    the

  • a décoloration of the urine;
  • the

  • a décoloration of sputum, sweat, tears or the skin;
  • the

  • a diarrhée (légère).
  • the

  • a stomach pain;
  • the

  • éructations;
  • the

  • a éeruption cutanée;
  • the

  • of the nausée;
  • the

  • indigestion;
  • the

  • vomiting.

most of The side effects listed ci-après are not très often, but they could, however, result in serious problèmes, if you do not receive the care mémedical.

Fill you withès of your médecin at t&taxes;t if one of the side effects ci-après manifest :

    the

  • joint pain or muscle pain;
  • the

  • a lack of strength, or d’éenergy;
  • the

  • symptoms&taxes;my of diarrhée associatedée to antibiotics (diarrhée, aqueous material which may contain blood);
  • the

  • symptoms&taxes;my associateés à inflammation of the eye (eye pain, brouillement of vision, redness, sensibilité à la lumière, floaters foncés in front of the eyes);
  • the

  • symptoms&taxes;my associateés à infection (such as the fièvre, or chills, a sore throat, sore t&stop;te, a weak généralisée).

Stop taking the médrug and seek imméimmediately care mémedical help if it occurs a réponse as a :

    the

  • chest pain;
  • the

  • symptoms&taxes;my due to active tb (such as cough, fièvre, loss of appétit, night sweats, and weight loss non-intentional);
  • the

  • symptoms&taxes;my due à réaction allergic important (such as the appearance of hives, difficultés breathing, or swelling of the face and throat).

Are there d'other prébonds d's employment, or warnings ?

Before using a médrug, do not miss to inform your médecin disorders mémedical or allergies you may have, médrugs that you are using and any other important fact about your santé. Women should mention if they are pregnant or if they are breastfeeding. These factors could have an influence on the fa&case;it is that you should use this médrug.

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Diarrhée associatedée à the use of antibiotics : médrug, like any other antibiotic, may cause a condition potentially dangerous callé pseudomembranous colitis, which is lié à taking antibiotics. The symptoms being limited to my have a brutal deportation of liquid stool that can &our vision to be bloody. If you observe these symptoms early;my, stop taking rifabutin and contact your médecin dès as possible.

body Fluids : it may be that your urine becomes brownâtre-orangée while you are taking this médrug. Your stool, your saliva, your spit, your sweat and your tears éalso change color.

contact Lenses : the brown colorationâtre-orangée of the body fluids may cause a dépermanent coloration of the lenses, cornécommunities that are flexible. This phénameèdo not touch the lenses rigid.

rénal : disease rénal or decrease of the function rénal can cause the accumulation of this médrug in the body, which causes side effects. If your rénal réinserted or if you &stop;your disease rénal, discuss with your médecin de la fa&case;one in which this médrug may affect your affection, the influence of your condition on the administration and the efficiencyé médrug, and the relevance of a monitoring mémedical spébe specific.

hépatique : a severe liver disease or réduction of the hépatique can result in an accumulation of this médrug in the body, causing side effects. In case of any disorders of the hépatiques, discuss with your médecin de la fa&case;one in which this médrug may affect your affection, the influence of your condition on the administration and the efficiencyé médrug, and the relevance of a monitoring mémedical spébe specific. Your médecin will monitor your hépatique through blood tests that he will prescribe régulièsurely while you are using this médrug.

Tb : persons who are infected with active tuberculosis should not use rifabutin. If you &stop;your suffering from this disease, or if you think l’&our vision to be, possibly (among the symptoms being limited to the esm, we find cough, the fièvre, a bad appétit, night sweats, and weight loss unintentional), include it to your médecin.

Pregnancy : médrug should not be used during pregnancy à less than the benefits prevail over the risks. If a pregnancy occurs while you are using this médrug, please contact your médecin imméimmediately.

Breastfeeding : it is not known whether rifabutin passes into breast milk. If you take this médrug while you are breastfeeding, your bébé could feel the effects. Consult your médecin to determine if you should continue breast-feeding.

Kids : or the innocuité or the effectivenessé médrug has not été éestablished in relation to children âgés under the age of 18 years.

D'other agents can interact with this médrug ?

There could be an interaction between rifabutin and one of the médrugs ci-après :

    the

  • abiratérone;
  • the

  • alpha-blockers (e.g. alfuzosin, doxazosin, silodosine, tamsulosin);
  • the

  • amiodarone and
  • the

  • antagonists of the sérotonine (the médrugs anti-éméticks; for example, the granisétron, the ondansétron);
  • the

  • calcium-antagonists (e.g. amlodipine, diltiazem, the nifédipine, the vérapamil);
  • the

  • macrolide antibiotics (e.g. clarithromycin, l’érythromycine);
  • the

  • anticancéto return (e.g. cabazitaxel, the docétaxel, doxorubicin, etoposide, ifosfamide, irinotécan, vincristine);
  • the

  • the antidépressers tricyclic (e.g. amitriptyline, imipramine, nortriptyline);
  • the

  • antidiabétick « gliptine » (e.g. the linagliptine, saxagliptin, sitagliptin);
  • the

  • anti-fungal type « azole » (e.g. fluconazole, itraconazole, the kétoconazole);
  • the

  • the apixaban;
  • the

  • aprépitant;
  • the

  • atovaquone;
  • the

  • barbiturates (e.g. butalbital, pentobarbital, phénobarbital);
  • the

  • BCG.
  • the

  • bédaquiline;
  • the

  • the benzodiazépines (e.g. alprazolam, diazépam);
  • the

  • b – &our vision to tabloquants (e.g. the métoprolol, the aténolol);
  • the

  • bosentan;
  • the

  • buprénorphine;
  • the

  • buspirone;
  • the

  • busulfan;
  • the

  • calcitriol;
  • the

  • carbamazépine.
  • the

  • chloroquine;
  • the

  • clofibrate;
  • the

  • clopidogrel.
  • the

  • the conivaptan;
  • the

  • oral contraceptives
  • the

  • corticostéroï (e.g. prednisone, hydrocortisone);
  • the

  • cyclosporine;
  • the

  • the dantrolèdo;
  • the

  • dapsone;
  • the

  • dasabuvir;
  • the

  • déférasirox;
  • the

  • dérivés nitrés (e.g. isosorbide dinitrate, isosorbide mononitrate);
  • the

  • digoxin;
  • the

  • disopyramide.
  • the

  • doxycycline.
  • the

  • dronabinol;
  • the

  • dronédarone;
  • the

  • elvitéto climb;
  • the

  • the enzalutamide;
  • the

  • l’éthosuximide;
  • the

  • l’évérolimus;
  • the

  • felbamate;
  • the

  • flutamide;
  • the

  • inhibitors of the phosphodiestérase-5 (e.g. sildénafil, tadalafil, vardénafil);
  • the

  • inhibitors of the pump à protons (e.g. the lansoprazole, the oméprazole);
  • the

  • inhibitors of the protéase of the héhepatitis C (e.g. the bocéprévir, the siméprévir, télaprévir);
  • the

  • inhibitors of the protéase of HIV (e.g. atazanavir, indinavir, ritonavir, saquinavir);
  • the

  • inhibitors of the tyrosine kinase (e.g. dabrafénib, dasatinib, imatinib, nilotinib);
  • the

  • inhibitors of non-familyéosidiques of the HIV reverse transcriptase (INNTIs; e.g. delavirdine, l’éfavirenz, l’étravirine, névirapine);
  • the

  • inhibitors sélectifs reuptake of the sérotonine (SSRIS, e.g. citalopram, duloxétine, fluoxétine, the paroxétine, sertraline);
  • the

  • isoniazid
  • the

  • lidocaïnot;
  • the

  • losartan.
  • the

  • the macitentan;
  • the

  • maraviroc;
  • the

  • some médrugs antipsychotic drugs (e.g. aripiprazole, clozapine, halo atréridol, quétiapine);
  • the

  • médrugs of type « statin » to treat levels élevés of cholestérol (e.g. atorvastatin, lovastatin, simvastatin);
  • the

  • méfloquine;
  • the

  • the mestranol;
  • the

  • méthadone;
  • the

  • the mexilétine;
  • the

  • mifépristone;
  • the

  • st. john’s wort;
  • the

  • mirtazapine;
  • the

  • modafinil;
  • the

  • montélukast;
  • the

  • the mycophénolate;
  • the

  • narcotic analgésiques (e.g. fentanyl, morphine, oxycodone);
  • the

  • natéglinide;
  • the

  • the néfazodone;
  • the

  • connection;strogènes (e.g. connection;strogènes conjugués, l’&cover;stradiol, l’éthinyl&cover;stradiol);
  • the

  • pérampanel;
  • the

  • phénobarbital;
  • the

  • phénytoïnot;
  • the

  • the sodium picosulfate;
  • the

  • pimozide;
  • the

  • praziquantel;
  • the

  • primaquine;
  • the

  • primidone;
  • the

  • progestins (e.g. acétate de médroxyprogestérone);
  • the

  • quinidine
  • the

  • quinine;
  • the

  • the raltéto climb;
  • the

  • répaglinide;
  • the

  • rifampin; or
  • the

  • the rilpivirine;
  • the

  • rivaroxaban.
  • the

  • the roflumilast;
  • the

  • the romidepsine;
  • the

  • sirolimus;
  • the

  • the sofosbuvir;
  • the

  • tacrolimus;
  • the

  • téniposide;
  • the

  • tétracycline;
  • théophyllines (e.g. aminophylline, oxtriphylline, théophylline);

    the

  • the ticagrélor;
  • the

  • ticlopidine;
  • the

  • tocilizumab;
  • the

  • the toltérodine;
  • the

  • the tolvaptan;
  • the

  • the trabectédine;
  • the

  • tramadol;
  • the

  • trazodone;
  • the

  • triméthoprime;
  • the

  • the vaccine, typhoï.
  • the

  • venlafaxine;
  • the

  • warfarin.
  • the

  • zolpidem.
  • the

  • zopiclone.

If you take one of these médrugs, consult your médecin or a pharmacist. In your case, your médecin could ask you :

    the

  • stop taking one of the médrugs;
  • the

  • replace one of the médrugs by another;
  • the

  • edit the manière that you take one of the médrugs, or both;
  • the

  • does not change anything at all.

The interférence of a médrug with another at any time entered cool;not always that you must stop taking one of them. Ask à your médecin what is the conduct to hold in case of interactions médicamenteuses.

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