> Chemotherapy effects on the skin

The antineoplastic drugs cause first a rapid decrease, and the important of the thick skin, and activity; mitotic keratinocytes, which lose their mobilityà and the capacity of the division, for which the regeneration from the skin is slowed. 

Decreases the vascularity and are damaged the collagen and elastic fibers of the dermis, which leads to a cute “loose”. Alters the regulation of sweat glands and sebaceous as well asé the tropism of the hair, with an increase of the dryness of the skin.

At the level of the cells pigment is inhibited the synthesis melanocitaria.

The alterations in clinical and histological caused by chemotherapy are also typical in the common processes of aging, which added to the effects of età lead to the early appearance or increase of wrinkles.

The use of new classes of drugs used in oncology, such as inhibitors of the receptor for the Epidermal Growth Factor (EGFr), the receptor is very active in the endothelial cells, has made in recent years, frequent skin reactions.

The toxic effect of the skin of this type of medication affects mainly the areas of seborrheic on the face, scalp and chest, with less frequency the endà and the back and presents itself as an acneiform eruption.  it Appears during the first two weeks of treatment, is accompanied by itching, very annoying, and può be complicated by additional bacterial infections.

The dryness of the skin and mucous membranes and has a variable incidence from 12% to 35% in clinical trials, and, often,  is one of the skin parameters that influence so constant, the qualityà of life of the patient.

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The diseases of the nails, onicopatie, are  present in approximately 10-20% of patients, are long lasting and therefore are highly disabling.

Of course the effect of the più known that scares the cancer patient is the alopecia induced by chemotherapeutic agents. The incidence and the entityà of alopecia vary depending on the drug taken, with frequencies più high especially for taxanes, anthracyclines, and alkylating agents.

alopecia acute scalp occurs 1 to 8 weeks from the start of chemotherapy, and is usually reversible. Cases of alopecia permanent chemotherapy, are associated with the administration of  busulfan  (50% of patients) and radiation  (related to the dose ( > 700 Gy ) .

Beard, eyelashes, eyebrows, pubic hair and armpits are affected by alopecia in the measurement variable, depends on the anagen phase of the hair at the beginning of the therapeutic cycle, and the duration and dosage of treatment.

Less frequent, but not less important, are the reactions of an unusualà (urticaria, vasculitis, erythema polymorphous, s. Steven Johnson, etc), alterations of the pigmentation of the skin, mucositis (oral and anal), and the reactions of photosensitization, which need an accurate assessment to optimize the selection of the protocol dermocosmetologico appropriate to the individual case.

IN ARGOMENTO:

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Wrinkles: treatments, natural remedies and prevention

“body found”

National Cancer Institute Regina Elena

Dermatological Institute San Gallicano

14 June 2013