> Alzheimer’s disease, the signals can be observed in età youth

Alzheimer’s disease, it is possible to identify the first signs in the youthù, when the disease is; così away from to appear foreign to the subject.

A recent research, carried out by the Banner Alzheimer’s Institute in Arizona, Boston University and the University of Antioquia, has found a form of the disease in some boys, about twenty years before symptoms develop.

The study, published in the magazine the Lancet Neurology, è was conducted on a group of boys among whom 30% had a mutation of the gene presenilin 1 (PSEN 1). A genetic mutation that predisposes to the early development of Alzheimer’s disease.

this, according to the scientists, a form of rare hereditary, which forò you can see the first signs of the disease before the developments in the real clinical symptoms.

The interest in the discovery, reads in the study, lies in the fact that once manifested the symptoms, the therapies may lose effectiveness becauseé the damage to the nervous system is now extended.

Here, then, is that if it were possible to prospectively identify the traces that predispose to Alzheimer’s disease, the clinical tests may be more appropriate, allowing the prevention of the disease.

The research involved 44 people with an age between 18 and 26 years old. At the time of the study none of the subjects presented cognitive problems.

After analyzing the blood,  the cerebrospinal fluid (Csf) and through the use of images in the brain, has been found that 20 of the participants had a mutation in the gene PSEN 1. Thereò, say the researchers, makes certain the development of Alzheimer’s disease.

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From the comparison with the group of 24, which had the genetic mutation, there were significant differences both in the structure and in the functioning of the brain.

The subjects with the genetic mutation in PSEN1 showed a higher activity; in the hippocampus, the area of the brain that is involved in memory. Moreover, the images of the brain have allowed to detect in certain areas of the brain with reduced grey matter.

the analysis of The cerebrospinal fluid has then allowed to measure high levels of beta-amyloid in subjects with the mutation of the gene.

The beta-amyloid is a protein, also the subject of recent studies, which plays a key role in the formation of amyloid plaques in the brain ‘off’ neurons, develop Alzheimer’s. This protein is usually present 10-15 years before the disease develop clinical symptoms, which is why it is identified as a biological marker key to Alzheimer’s disease.

typically the subjects with the gene mutation PSEN 1 show the first cognitive problems around the age of 45, the search forò has been shown to be able to identify the biological markers of Alzheimer’s disease long before the disease manifests itself, with nearly 20 years of advance.

Eric Reimn, one of the researchers, explained that “These findings suggest that brain changes begin many years before the clinical manifestation of Alzheimer’s disease and even before the deposition of amyloid plaques. Emerge new questions about the earliest brain changes involved in the predisposition to Alzheimer’s disease and on the extent in which they can be identified for future preventive therapies”.

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Per approfondire:

Alzheimer’s disease, have identified the protein maybe responsible for the disease

6 November 2012