We have developed a technique that allows you to transform the fibroblasts, skin cells, oligodendrocytes, i.e. cells in the brain. The discovery could in the future allow for the development of treatments for diseases such as multiple sclerosis.
us researchers at Case Western Reserve School of Medicine have published the results of their experimentation on the Nature Biotexchnology.
For now, the research has been performed on mice, but if confirmed by subsequent studies, the discovery could open the way towards a new modeà of care for the diseases that involve the Myelin.
The myelin is, in fact, the sheath that protects and surrounds the cells of the brain, and that allows for the transmission of electrical impulses.
Many medical conditions also depend on a lack of this sheath or by his or her inadequate functioning.
The result reached by the researchers is to transform the cells of the adipose tissue in oligodendrocytes, that is, the brain cells that form the myelin.
Paul Tesar, coordinator of the study, has defined the process as “alchemy mobile”, thanks to which è was possible to obtain a change of identityà of the cells, so that you can have the ability to start a production “on demand” .
Starting, then, by a simple and easily accessible cell, such that of the skin, you canò turn on “cellular reprogramming” to create the cells that will have a great therapeutic value.
The process described by Tesar provides the handling of three proteins that causes the cell to change, and to generate oligodendrocytes and not più fibroblasts.
The technique has così allowed to produce a few billion new cells that, when transplanted in mice, they will be able to regenerate the myelin.
it will Take further steps to ensure the feasibilityà of the road travelled by the researchers. The first sarà to use human cells in a laboratory environment.
If the experimentation avrà the success, the process identified may be used for the development of treatments for diseases such as multiple sclerosis, cerebral palsy and other neurological disorders involving cells of the myelin.
multiple Sclerosis, in Italy, affects 43 million women
Stem cells from skin cells, a therapeutic avenue for multiple sclerosis