> Stem from the cells of the skin, a therapeutic avenue for multiple sclerosis

the brain Stem obtained from the transformation of the cells of the skin. According to a study, it is possible that they will become in the future a therapy for the treatment of diseases of the central nervous system, for example, multiple sclerosis.

The research, published on the magazine Nature Communications, è was completed  by the Institute of experimental Neurology (INSpe) at San Raffaele Hospital in Milan, with the collaboration of the group of Elena Cattaneo Università degli Studi of Milan.

The work has been funded by the Italian Association of Multiple Sclerosis and, above all,  by the National Multiple Sclerosis Society.

The scholars, coordinated by Gianvito Martino, have been able to observe in the experiments on mice that the skin cells transformed into stem cells of the brain and subsequently transplanted in an experimental model of multiple sclerosis, have the capacity to repair the damage characteristic of the disease causes the myelin.

The multiple sclerosis is a neurological disease, who is affected progressively lose muscle control. Even if the reasons are not yet clear, the immune system starts to produce antibodies that attack myelin, a fatty insulator of nerve cells that ensures the proper conduction of nervous impulses.

Here is the importance of the discovery, the procedure adopted was già well known, but what still was missing was the verification of the therapeutic potential expressed by these cells in the field of inflammatory diseases of the central nervous system.

in Fact, so far the main approach to the treatment of the disease is that interfere with the immune system through the administration of drugs. It is forò therapies which do not produce beneficial effects when multiple sclerosis is in the advanced stage, when that is; the myelin is now damaged.

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Now there is talk of the rebuilding of the myelin and, according to experts, the results obtained with this study can be considered as a step forward towards developing therapies that can repair the damage caused by multiple sclerosis, by the rebuilding of the areas of myelin are damaged.

Martin explains that “the discovery opens up new prospects for sufferers of multiple sclerosis sinceé could represent the basis for the future development of innovative therapies based on stem cells, able to deal with the disease even when it is; già established, and the nervous system of the sick è già compromise.

The procedure also has the advantage of the shelter the patient from possible rejection. In fact, the cells of the skin can be taken from the same patient and then be transformed into stem cells of the brain through a process of cellular reprogramming.

This last è già well known, discovered by the japanese Shinya Yamanaka and britain’s John Gordon, who in 2012 received the Nobel prize for Science, and Physiology, have shown that the cells già the adult can go back and transforming into cells able to specialize again in a different way than before.

What was not yet known, as we explained before, is the therapeutic potential of the cells obtained with this procedure.

With the results of this study, the all-Italian the way it is drawn, even if “is still long, even if the conditions are all there. The hope is then that in the next few years – explains Martino – all this effort can lead to an improvement of the armamentarium of treatment and disposal of the sick with multiple sclerosis”.

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estimates indicate that about 2.3 million people in the world are living with multiple sclerosis, of these, 68 thousand reside in Italy.

The disease, which is recorded each year thousands of new cases, it attacks mainly young adults. It is in reality a medical emergency, and social with human and social costs very high.


multiple Sclerosis, part experimentation with the stem on the first patient

multiple Sclerosis, cells of the skin to the brain to regenerate myelin

31 October 2013