> Down syndrome, mice with a successful treatment with the antidepressant

Could be an antidepressant medication to restore the normal development of the brain affected by Down syndrome. Explain in the journal of neuroscience, “Brain” the researchers of the Department of Biomedical Sciences and Neuromotor of the Università di Bologna.

For now this is an experimentation carried out on a specific model lab rat but, argue the scientists, the results open the way to possible treatment for the man.

novità research, stress the researchers, lies in the fact that for the first time has been shown how it is possible to correct in the laboratory, with a drug therapy, and prenatal damage cognitive and brain produced by the Down syndrome.

Are some years that the researchers, coordinated by Renata Bartesaghi, studies on mice altered the ability to replicate the features of the Down syndrome. The experimentation, making use of drug treatments based on fluoxetine,  then tried to restore with success, in mice just born, the normal functions in brain development.

fluoxetine (Fluoxetine hydrochloride) is an antidepressant selective inhibitor of serotonin reuptake (SSRIS) in the central neurons, which is used for the treatment of depressive disorders.

After years of research by the scholars of the Alma Mater have così obtained a positive feedback that will help formulate other hypotheses of work.

The majority of the neurons of the brain, explained the scientists, will form in the fetus, unlike the neurons that populate the region ippocampica the development of which takes place predominantly after the birth. Therefore, the prenatal period è the più sensitive and critical for development of brain physiological.

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On this evidence the team of researchers sought to test the ability to rehabilitate in a meaningful way the development of the brain, using drugs just before birth. A new road never traveled before, from experimentation in the  laboratory, has shown that the antidepressant fluoxetine administered in the prenatal phase allows the recovery of brain development affected by Down syndrome.

novità è significant but it is important to be cautious, as he explains, in fact Bartesaghi sarà necessary to proceed with the clinical trial “that we willà to say if the drug therapy, così to be effective in this mouse model with Down syndrome, willà to get the same positive results on the man”.


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