> Gynaecological problems are common linked to Chronic Fatigue Syndrome

Roumiana S. Boneva, MD, PhD, of the Centers for Disease Control and Prevention, Atlanta, Georgia, and colleagues, present their results in an article published online on February 2, in Menopause.

The CFS, also known as myalgic encephalomyelitis, “is a debilitating and complex that it affects more than a million american adults and is the economic costs are considerable for the individual, for the health system and for the company; as a whole”, the authors write. “The CFS is characterised by profound fatigue, accompanied by symptoms that affect multiple systems of the body, including the più the characteristic discomfort post exercise, sleep, non-restorative, problems with memory and concentration and pain.”

The researchers analyzed data from a subset of 157 women (of which 84 with CFS and 73 healthy women and subsidiaries) who have participated in the phase of follow-up in a longitudinal study about the CFS and the disease are not tiring, conducted between 2004 and 2009.

The women completed a questionnaire autosomministrato on lorostoria gynecologic based on the Reproductive History Questionnaire/Menstruation-Menopause History, developed by the National Cancer Institute Division of Cancer Epidemiology and Genetics. The women in both groups were divided for età.

After adjustment for the body mass index, and other potential confounders, women with CFS describe conditions gynaecological and surgical interventions più significant compared to those of the control group (menopause in 61,9% vs. 37,0% [the ratio of the probability; (OR), to 2.37; 95% confidence interval (CI), 1,21-4,66; età mean early menopause, 37,6 vs 48.6 years [OR adjusted; 1.22; 95% CI, 1,09-1,36], excessive menstrual bleeding, 48,8% vs 23,3% [OR adjusted to 3.31; 95% CI, 1,60 – 6,86]; and endometriosis, a 29.8 % vs. 12.3 percent [OR adjusted, 3,67; 95% CI, 1.53 a – 8,84], respectively.

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women with CFS have also reported significant increase in the pelvic pain is not menstrual (at 26.2% vs 2.7% OR adjusted, 11,98; 95% CI, 2.57 bcm – 55,81), use of hormonal preparations is not contraceptive (57.1% vs 26.0%; OR adjusted, 2.95; 95% CI, 1.36 – 6.38) and gynaecological surgery (65.5% vs 31.5%; OR adjusted, 3.33; 95% CI, 1.66 – 6.67), in particular, l’hysterectomy (54.8% vs 19.2%; OR adjusted, 3.23; 95% CI, 1.46 – 7.17), compared to control women.

The women in the group CFS have undergone a hysterectomy and an oophorectomy to a età media significantly più young in comparison to that of women in the control group.

Hysterectomy and oophorectomy were performed before the onset of CFS in 71% of cases with available information on the dates of the surgery and the onset of the CFS.

“The CFS in women is associated to abnormalities in self-reported menstrual abnormalities, endometriosis, pelvic pain not related to menstruation, early age of surgical menopause, and other gynecological conditions and surgical operations”, the authors write. “It should be stressed, however, that our results do not prove causalità. These results could be used to generate further hypotheses in future studies. However, the prevalence of various gynaecological conditions in women with CFS advised, however, to the clinicians to personalize the treatment in these patients.”

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