The study has been completed by scholars at the Università of Sydney and published in the Journal of the American Heart Association.
A drug so widespread, and low cost as the colchicine could, according to australian researchers, to be the key to saving the lives of victims of a heart attack.
Sanjay Patel, the chief investigator of the study and scientist cardiovascular at the Research Institute of Heart, she found that the medicine può significantly improve heart health by lowering levels of inflammatory proteins as dangerous.
colchicine is an anti-inflammatory that è long been used to treat arthritis caused by gout, but dr. Patel explained that another feature is that of drastically reducing the levels of some inflammatory proteins specific to that found in people with heart disease.
dr. Patel has clarified that “if we will be able to demonstrate its success in studies of the più large, we will have a new therapy that willà to help enormously the prospects for people who suffer heart attacks”.
The research studied 40 people who had an acute coronary syndrome, a life-threatening condition in which the coronary artery is blocked causing a heart attack or severe chest pain.
The researcher then added that “we know from pathological anatomy and histology, that when you analyze the coronary arteries of patients who died, the plates are full of inflammatory markers and proteins, confirming that the inflammation is really involved in every stage of the disease”.
The associate professor Clara Chow, the Heart Foundation of the Università of Sydney, said that the result has been particularly important becauseé the target of the study is the inflammation.
Chow has adding that “the majority of our treatments are made to try to reduce the blood pressure or cholesterol or decrease the capacity of blood clotting, then this model of intervention is different, becauseé it targets the inflammation, and this is a lens entirely new and innovative”.
According to professor Chow, “we do not know really whyé the inflammation is occurring, but there have been a number of observational studies which have shown that it is, probably, the cause of the blockage of the coronary arteries”.
The studies should now focus on one hand in identifying the correct dose, and in the other side in order to solve a problem that the intake of colchicine può cause, namely diarrhea, that may lead many patients to be reluctant to take the medication.
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